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Glucosamine Abstract
Glucosamine Abstract
A Large, Randomized, Placebo Controlled, Double-Blind Study of Glucosamine
Sulfate vs Piroxicam and vs Their Association, on the Kinetics of the
Symptomatic Effect in Knee Osteoarthritis
Author(s): L.C. Rovati, G. Giacovelli, M. Annefeld, R.L. Dreiser, and B.
Avouac
Source: Osteoarthritis and Cartilage - Vol. 2, Supplement 1, December 1994
Second International Congress of the Osteoarthritis Research Society
Orlando, Florida 9-11 December 1994
Abstract:
Methods: 329 patients (245 women, 84 men; median age 67 years) were
enrolled in this multicentre study and randomized in 4 homogenous groups.
The following once-a-day oral treatments were given for 90 days: 1) 1500 mg
glucosamine sulfate (GS); 2) 20 mg piroxicam (Pir); 3) their association
(GS+Pir); 4) placebo (Plac). Patients were then followed-up for further 60
days without treatment. The main efficacy variable was represented by the
Lequesne index.
Results: Analysis of variance for repeated measures was performed according
to an intention to treat approach (last value carried forward) on the 310
evaluable patients, including drop-outs for inefficacy, worsening, or
concomitant use of other symptomatic drugs. There were significant
(p=0.0001) treatment effects, time effects and treatment time
interactions. Adverse events during treatment were present in 19 patients
with Plac (i.e. 24.4%, yielding 3 drop-outs: d-o), 12 with GS (14.8%, no d-
o), 36 with Pir (40.9%, 20 d-o) and 28 with the association (35.9%, 3 d-o):
p=0.0001.Conclusion: GS was confirmed an effective and well tolerated
Symptomatic Slow Acting Drug in OA, with a steadily increasing effect,
persisting after drug withdrawal. Pir was less tolerated, had a similar
efficacy at the beginning of treatment, but that wore off at
withdrawal.
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